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Abbreviations 2-AG: 2-Arachidonylglycerol A2A: Adenosine A2A receptor ACE2: Angiotensin converting enzyme 2 AEA: Anandamide ALI: Acute lung injury APC: Antigen-presenting cell ARDS: Acute respiratory distress syndrome cAMP: Cyclic adenosine monophosphate CB1: Cannabinoid receptor 1 CB2: Cannabinoid receptor 2 CBC: Cannabichromene CBD: Cannabidiol CBE: Cannabielsoin CBG: Cannabigerol CBGA: Cannabigerolic acid CBL: Cannabicyclol CBN: Cannabinol CBND: Cannabinodiol CBR: Cannabinoid receptor CBT: Cannabitriol CNS: Central nervous system COPD: Chronic obstructive pulmonary disease COVID-19: Coronavirus-induced disease-19 DC: Dendritic cell eCO: Exhaled carbon monoxide ECS: Endocannabinoid system EVALI: The e-cigarette product use associated lung injury FAAH: Fatty acid amide hydrolase G i : G-inhibitory alpha subunit GPCR: G-protein coupled receptor G : G beta-gamma dimer IBD: Inflammatory bowel disease IFN: Interferon HIV: Human immunodeficiency virus K i : Inhibitory constant IM: Interstitial macrophage LPS: Lipopolysaccharide MEP: Methylerythritol phosphate M1: Classically activated macrophages M2: Alternatively activated macrophages MAGL: Monoacylglycerol lipase MAPK: Mitogen-activated protein kinase MCP-1: Monocyte chemoattractant protein-1 MMP: Matrix metalloproteinase MS: Multiple sclerosis NF-B: Nuclear factor kappa-light-chain-enhancer of activated B cells NK: Natural killer cell NO: Nitric oxide PBMC: Peripheral blood mononuclear cells PK: Pharmacokinetics PKA: Protein kinase A PPAR: Peroxisome proliferator activated receptor ROS: Reactive oxygen species SARS-CoV-2: Severe acute respiratory syndrome-coronavirus-2 T1D: Type 1 diabetes Th1: T-helper type 1 Th2: T-helper type 2 TLR: Toll-like receptor T reg : Regulatory T cell TRP: Transient receptor potential channel 9 -THC: Delta-9-tetrahydrocannabinol 9 -THCA: Delta-9-tetrahydrocannabinolic acid VEA: Vitamin E acetate References Small E

Some of the toxins in cigarettes affect the mouth, throat and lungs, while others enter the entire body via the bloodstream

However, we cannot rule out the possibility that longer exposure may affect cardiac function and structure, even in younger rats

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